These results are not consistent with the above-mentioned speculations; however, they support our opinion that this suppression of postirradiation upregulation of HIF-1 activity is usually most important for the best therapeutic benefit. This study raises the important possibility that other strategies that lead to an increase in tumour hypoxia might have the same negative influence … Continue reading These results are not consistent with the above-mentioned speculations; however, they support our opinion that this suppression of postirradiation upregulation of HIF-1 activity is usually most important for the best therapeutic benefit